Summary

Name cyclosporin A
Synonyms (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) (ChEBI), 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine] (JCBN), 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone (ChEBI), Antibiotic S 7481F1 (ChemIDplus), ciclosporin (KEGG DRUG), Ciclosporin (KEGG COMPOUND), ciclosporina (ChemIDplus), ciclosporine (ChemIDplus), ciclosporinum (ChemIDplus), Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl) (ChemIDplus), Cyclosporin A (KEGG COMPOUND), Cyclosporine (KEGG COMPOUND), Cyclosporine (ChemIDplus), Gengraf (DrugBank), Neoral (DrugBank), Sandimmune (DrugBank)
IUPAC 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Formula C62H111N11O12
PRIMARY ID
(Read more)		 CHEBI:4031
Type chemical
Relations 7
Pathways Focal segmental glomerulosclerosis, Satellite: Calcium&myogenesis

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Relations

Regulator Mechanism target score ℹ
+ cyclosporin Adown-regulates img/direct_inhibition.png chemical inhibition PPP3CC 0.8
Publications: 1 Organism: Homo Sapiens
+ cyclosporin Adown-regulates img/direct_inhibition.png chemical inhibition PP2B 0.8
Publications: 1 Organism: Homo Sapiens
+ cyclosporin Aup-regulates img/indirect-activation.png TTN 0.8
Publications: 1 Organism: Homo Sapiens
+ cyclosporin Adown-regulates img/direct_inhibition.png chemical inhibition PPP3CB 0.8
Publications: 1 Organism: Homo Sapiens
+ cyclosporin Adown-regulates img/direct_inhibition.png chemical inhibition PPP3CA 0.8
Publications: 1 Organism: Homo Sapiens
+ cyclosporin Adown-regulates img/direct_inhibition.png chemical inhibition Calcineurin 0.8
Publications: 2 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Focal segmental glomerulosclerosis