| + |
Calcineurin | up-regulates activity 
dephosphorylation
|
NFATC2 |
0.665 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252319 |
Ser168 |
YREPLCLsPASSGSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252318 |
Ser171 |
PLCLSPAsSGSSASF |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252316 |
Ser172 |
LCLSPASsGSSASFI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252326 |
Ser174 |
LSPASSGsSASFISD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252343 |
Ser175 |
SPASSGSsASFISDT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252325 |
Ser177 |
ASSGSSAsFISDTFS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252327 |
Ser180 |
GSSASFIsDTFSPYT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252329 |
Ser213 |
QNIPAHYsPRTSPIM |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252330 |
Ser217 |
AHYSPRTsPIMSPRT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252331 |
Ser221 |
PRTSPIMsPRTSLAE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252342 |
Ser268 |
VALPPGAsPQRSRSP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252328 |
Ser274 |
ASPQRSRsPSPQPSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252333 |
Ser276 |
PQRSRSPsPQPSSHV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252336 |
Ser280 |
RSPSPQPsSHVAPQD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252335 |
Ser326 |
PPKMWKTsPDPSPVS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11030334 |
NFAT1 is phosphorylated on fourteen conserved phosphoserine residues in its regulatory domain, thirteen of which are dephosphorylated upon stimulation. Dephosphorylation of all thirteen residues is required to mask a nuclear export signal (NES), cause full exposure of a nuclear localization signal (NLS), and promote transcriptional activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255463 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
16 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
Calcineurin | up-regulates activity
dephosphorylation
|
CACNA1H |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277872 |
Ser2137 |
RDLRRLYsVDAQGFL |
Mus musculus |
CAD Cell |
| pmid |
sentence |
| 38001892 |
we also discovered that a novel CaMKII-phosphorylated site, S2137, underwent dephosphorylation by calcineurin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Calcineurin | down-regulates 
dephosphorylation
|
FLNA |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252339 |
Ser2152 |
TRRRRAPsVANVGSH |
Homo sapiens |
|
| pmid |
sentence |
| 16442073 |
We report that a purified c-terminal recombinant region of filamin is a suitable substrate for calcineurin in vitro. Furthermore, 1 microm cyclosporin a (csa), a specific calcineurin inhibitor, reduced the dephosphorylation of the recombinant fragment in 293ft cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates activity
dephosphorylation
|
DNM1L |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252315 |
Ser637 |
VPVARKLsAREQRDC |
Homo sapiens |
|
| pmid |
sentence |
| 18838687 |
When mitochondrial depolarization is associated with sustained cytosolic Ca(2+) rise, it activates the cytosolic phosphatase calcineurin that normally interacts with Drp1. Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin |
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4.0
Calcineurin