4.0
Summary
| Name |  lapatinib
|
| Synonyms | GW 572016 (ChemIDplus), N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine (ChemIDplus), N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE (PDBeChem), Tykerb (ChemIDplus) |
| IUPAC | N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine |
| Formula | C29H26ClFN4O4S |
| PRIMARY ID (Read more) |
CHEBI:49603 |
| Type | chemical |
| Relations | 9 |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | lapatinib | down-regulates 
chemical inhibition
|
ERBB2 | 0.8 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
RET | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
EGFR | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | lapatinib | down-regulates
chemical inhibition
|
EGFR | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
KDR | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
ERBB2 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
KIT | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | lapatinib | down-regulates activity
chemical inhibition
|
CSK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |