Summary

Name CSK
Full Name Tyrosine-protein kinase CSK
Synonyms C-Src kinase, Protein-tyrosine kinase CYL
Primary ID P41240
Links - -
Type protein
Relations 17
Inhibitors lapatinib
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CSK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPRC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CSK 0.28
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GSN 0.14
Publications: 5 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation LCK 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LYN 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FGR 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation SRC 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CSK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CSK 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSK 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITCH 0.14
Publications: 1 Organism: Homo Sapiens