Summary

Name CSK
Full Name Tyrosine-protein kinase CSK
Synonyms C-Src kinase, Protein-tyrosine kinase CYL
Primary ID P41240
Links - -
Type protein
Relations 13
Pathways EBV infection, Mitochondrial dynamics in T cell exhaustion, T cell activation
Inhibitors lapatinib
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CSK 0.345
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPRC 0.481
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation CSK 0.2
Publications: 1 Organism: In Vitro
Pathways:EBV infection, T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation LCK 0.521
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation LYN 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ down-regulates activity img/direct_inhibition.png phosphorylation FGR 0.52
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation SRC 0.554
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PECAM1 0.534
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/indirect-activation.png CSK 0.354
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ up-regulates img/direct-activation.png binding CSK 0.518
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CSK 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITCH 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.284
Publications: 1 Organism: Homo Sapiens