| + |
coenzyme A(4-) | up-regulates quantity 
precursor of
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271825 |
|
|
|
|
| pmid |
sentence |
| 10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
| Publications: |
1 |
| Pathways: | Aspartate and asparagine metabolism |
| + |
acetate | up-regulates quantity
precursor of
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271824 |
|
|
|
|
| pmid |
sentence |
| 10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
| Publications: |
1 |
| + |
ACAA2 | down-regulates quantity 
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38656551 |
Acetyl-CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes the final step of mitochondrial β oxidation, which plays an important role in fatty acid metabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACSS3 | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271832 |
|
|
|
|
| pmid |
sentence |
| 10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
| Publications: |
1 |
| + |
NAT8L | down-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19524112 |
The biosynthetic enzyme, aspartate-N-acetyltransferase (Asp-NAT; EC 2.3.1.17) is a CNS specific enzyme that catalyzes the transfer of acetate from acetyl-CoA to L-aspartate forming NAA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Aspartate and asparagine metabolism |
| + |
ACSS1 | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271829 |
|
|
|
|
| pmid |
sentence |
| 10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
| Publications: |
1 |
| + |
acetoacetyl-CoA(4-) | up-regulates quantity
precursor of
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280428 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31268215 |
The mitochondrial acetoacetyl‐CoA thiolase (commonly known as β‐ketothiolase [T2]; EC 2.3.1.9; encoded by the ACAT1 gene) is a ubiquitous and important enzyme for ketone body synthesis and degradation as well as in isoleucine catabolismIn the biosynthetic direction, thiolases catalyze the formation of a carbon‐carbon bond through a Claisen condensation mechanism (from two acetyl‐CoA molecules) and in the reverse, degradative direction a C‐C bond is broken through thiolysis (in the presence of CoA), resulting in chain shortening of the acyl chain by two carbon atoms (in case the substrate is an unbranched acyl chain) or by three atoms (in case the substrate is a 2‐methyl‐branched acyl chain), such as for example catalyzed by the T2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
acetyl-CoA(4-) | up-regulates quantity
precursor of
|
coenzyme A(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19524112 |
The biosynthetic enzyme, aspartate-N-acetyltransferase (Asp-NAT; EC 2.3.1.17) is a CNS specific enzyme that catalyzes the transfer of acetate from acetyl-CoA to L-aspartate forming NAA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Aspartate and asparagine metabolism |
| + |
Trifunctional enzyme | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29551309 |
The second step in the β-oxidation of fatty acids is the hydration of the trans-double bond to generate a 3-l-hydroxyacyl-coA ester, catalyzed by enoyl-coA hydratase. In the third step, 3-l-hydroxyacyl-coA dehydrogenase catalyzes the oxidation of the 3-l-hydroxyacyl-coA ester to a 3-ketoacyl-coA intermediate while NADH is generated from NAD+. The fourth and final step is the thiolytic cleavage of the chain by a ketothiolase, generating acetyl-coA and a fatty-acyl-coA two carbon atoms shorter. This shortened acyl-coA ester may start again the oxidation cycle. (Fig. 3) In humans, a single enzyme catalyzes the three last steps in the β-oxidation of long-chain fatty acids, the mitochondrial trifunctional protein (MTP) complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACSS2 | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271826 |
|
|
|
|
| pmid |
sentence |
| 10843999 |
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP. |
|
| Publications: |
1 |
| + |
acetyl-CoA(4-) | up-regulates quantity
precursor of
|
3-oxo-fatty acyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280392 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38656551 |
Acetyl-CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes the final step of mitochondrial β oxidation, which plays an important role in fatty acid metabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACAT1 | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280427 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31268215 |
The mitochondrial acetoacetyl‐CoA thiolase (commonly known as β‐ketothiolase [T2]; EC 2.3.1.9; encoded by the ACAT1 gene) is a ubiquitous and important enzyme for ketone body synthesis and degradation as well as in isoleucine catabolismIn the biosynthetic direction, thiolases catalyze the formation of a carbon‐carbon bond through a Claisen condensation mechanism (from two acetyl‐CoA molecules) and in the reverse, degradative direction a C‐C bond is broken through thiolysis (in the presence of CoA), resulting in chain shortening of the acyl chain by two carbon atoms (in case the substrate is an unbranched acyl chain) or by three atoms (in case the substrate is a 2‐methyl‐branched acyl chain), such as for example catalyzed by the T2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACAT1 | down-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280430 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31268215 |
The mitochondrial acetoacetyl‐CoA thiolase (commonly known as β‐ketothiolase [T2]; EC 2.3.1.9; encoded by the ACAT1 gene) is a ubiquitous and important enzyme for ketone body synthesis and degradation as well as in isoleucine catabolismIn the biosynthetic direction, thiolases catalyze the formation of a carbon‐carbon bond through a Claisen condensation mechanism (from two acetyl‐CoA molecules) and in the reverse, degradative direction a C‐C bond is broken through thiolysis (in the presence of CoA), resulting in chain shortening of the acyl chain by two carbon atoms (in case the substrate is an unbranched acyl chain) or by three atoms (in case the substrate is a 2‐methyl‐branched acyl chain), such as for example catalyzed by the T2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
acetyl-CoA(4-)