| + |
MDH1 | up-regulates quantity 
chemical modification
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266287 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Malate is dehydrogenated to produce oxaloacetate by the enzyme Malate Dehydrogenase. In this reaction NAD is converted to NADH2. Oxaloacetate formed in this reaction reacts with acetyl-CoA to form citrate in order to start another round of the citric acid cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDH2 | up-regulates quantity
chemical modification
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24068518 |
Malate is dehydrogenated to produce oxaloacetate by the enzyme Malate Dehydrogenase. In this reaction NAD is converted to NADH2. Oxaloacetate formed in this reaction reacts with acetyl-CoA to form citrate in order to start another round of the citric acid cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAD(1-) | up-regulates quantity
precursor of
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268113 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IDH | down-regulates quantity 
chemical modification
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IDH | up-regulates quantity
chemical modification
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OGDC | up-regulates quantity
chemical modification
|
NADH |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
The α-ketoglutarate–dehydrogenase complex is a complex including multiple copies of three proteins: E1k (α-ketoglutarate dehydrogenase), E2k (dihydrolipoyl succinyltransferase), and E3 (dihydrolipoamide dehydrogenase) (Fig. 2). The consecutive action of the three catalytic components of KGDHC results in oxidative decarboxylation of 2-oxoglutarate, preserving the energy in the form of succinylCoA and NADH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NADH