4.0
Summary
| Name |  MDH1View Modifications |
| Full Name | Malate dehydrogenase, cytoplasmic |
| Synonyms | Cytosolic malate dehydrogenase, Diiodophenylpyruvate reductase, 1.1.1.96 | MDHA |
| Primary ID | P40925 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | Citric acid cycle - Krebs cycle, Fatty Acid Synthesis |
| Function | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CARM1 | down-regulates activity 
acetylation
|
MDH1 | 0.356 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDH1 | down-regulates quantity
chemical modification
|
NAD(1-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDH1 | down-regulates quantity
chemical modification
|
(S)-malate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle, Fatty Acid Synthesis | |||
| + | MDH1 | up-regulates quantity 
chemical modification
|
oxaloacetate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle, Fatty Acid Synthesis | |||
| + | MDH1 | up-regulates quantity
chemical modification
|
NADH | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |