| + |
glutamine | up-regulates quantity 
|
AminoAcids |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264751 |
|
|
|
|
| pmid |
sentence |
| 29259120 |
All extant life employs the same 20 amino acids for protein biosynthesis |
|
| Publications: |
1 |
| + |
glutamine | up-regulates activity 
|
mTORC1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268008 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22749528 |
Leucine and Glutamine Activate Glutaminolysis and mTORC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268012 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 27126896 |
Importantly, asparagine/glutamine pre-load only results in mTOR activation following amino acid stimulation (Fig. 5a), indicating that it is their exchange factor roles that elicit mTORC1 activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GLS2 | down-regulates quantity 
chemical modification
|
glutamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266909 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22049910 |
Glutaminase (GLS1/2) catalyzes the conversion of L-glutamine to L-glutamate and ammonia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamine | up-regulates quantity
precursor of
|
Gln-tRNA(Gln) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28271488 |
Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate one tRNA molecule by the cognate amino acid. In mammals, nine synthetases, those specific for amino acids Arg, Asp, Gln, Glu, Ile, Leu, Lys, Met and Pro, associate into a multi-aminoacyl-tRNA synthetase complex, an association which is believed to play a key role in the cellular organization of translation, but also in the regulation of the translational and nontranslational functions of these enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Multiaminoacyl-tRNA synthetase | down-regulates quantity
chemical modification
|
glutamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28271488 |
Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that specifically aminoacylate one tRNA molecule by the cognate amino acid. In mammals, nine synthetases, those specific for amino acids Arg, Asp, Gln, Glu, Ile, Leu, Lys, Met and Pro, associate into a multi-aminoacyl-tRNA synthetase complex, an association which is believed to play a key role in the cellular organization of translation, but also in the regulation of the translational and nontranslational functions of these enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamine | up-regulates activity
|
Glutaminolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268009 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22749528 |
Leucine and Glutamine Activate Glutaminolysis and mTORC1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAD | down-regulates quantity
chemical modification
|
glutamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24332717 |
In animals, the first three reactions of the pathway are catalyzed by CAD, an 240 kDa multifunctional protein that combines glutamine-dependent carbamyl phosphate synthetase (GLNCPSase), aspartate transcarbamylase (ATCase), and dihydroorotase (DHOase) activities |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CPS1 | down-regulates quantity
chemical modification
|
glutamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267198 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15096496 |
CPSase catalyzes the synthesis of carbamoyl phosphate from glutamine, bicarbonate, and two ATP molecules |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
glutamine