Summary

Name GLS2
Full Name Glutaminase liver isoform, mitochondrial
Synonyms GLS, L-glutaminase, L-glutamine amidohydrolase | GA
Primary ID Q9UI32
Links - -
Type protein
Relations 4
Pathways Glutamine metabolism
Function Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

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Relations

Regulator Mechanism target score ℹ
+ GATA3up-regulates quantity by expression img/direct-activation.png transcriptional regulation GLS2 0.34
Publications: 1 Organism: Homo Sapiens
+ GLS2down-regulates quantity img/direct_inhibition.png chemical modification glutamine 0.8
Publications: 1 Organism: Homo Sapiens
+ TP53up-regulates quantity by expression img/direct-activation.png transcriptional regulation GLS2 0.618
Publications: 1 Organism: Homo Sapiens
+ GLS2up-regulates quantity img/direct-activation.png chemical modification L-glutamate(1-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamine metabolism