Summary

Name TNFRSF10A
Full Name Tumor necrosis factor receptor superfamily member 10A
Synonyms Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1 | APO2, DR4, TRAILR1, APO2, DR4, TRAILR1
Primary ID O00220
Links - -
Type protein
Relations 3
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding TNFRSF10A 0.98
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown TNFRSF10A 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FADD 0.74
Publications: 1 Organism: Homo Sapiens