4.0
Summary
| Name |  TNFRSF10A
|
| Full Name | Tumor necrosis factor receptor superfamily member 10A |
| Synonyms | Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1 | APO2, DR4, TRAILR1, APO2, DR4, TRAILR1 |
| Primary ID | O00220 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MARCHF8 | down-regulates quantity 
ubiquitination
|
TNFRSF10A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNFRSF10A | up-regulates 
binding
|
FADD | 0.831 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RIPK1 | up-regulates 
|
TNFRSF10A | 0.628 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNFSF10 | up-regulates
binding
|
TNFRSF10A | 0.933 |
| Publications: | 1 | Organism: | Homo Sapiens | |