| + |
TNFRSF10C | down-regulates 
binding
|
TNFSF10 |
0.896 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20103630 |
Albeit on binding the ligand, dcr1 and dcr2 do not transduce the apoptogenic signal, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TNFSF10 | up-regulates 
binding
|
TNFRSF10B |
0.932 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101313 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Trail interacts with tril-r1 and trail-r2 and activetes them |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15766588 |
Tumour necrosis factor-related apoptosis inducing ligand (trail) receptor 2 (trail-r2) also known as tnfrsf10b (tumour necrosis factor receptor (tnfr) super family 10b) or killer/dr5, a member of the tnfr family, is a promising candidate tumour suppressor gene at 8p21-22. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | down-regulates quantity by repression 
transcriptional regulation
|
TNFSF10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
FBP1 down-regulates cell cycle inhibitors and proapoptotic genes. Interestingly, we also observed the up-regulation of proapoptotic genes following FBP1 knockdown in Hep3B cells. In addition, mRNA levels of the death ligands tumor necrosis factor (TNF) α and tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) were significantly increased. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFSF10 | up-regulates
binding
|
TNFRSF10A |
0.932 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101082 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Trail interacts with tril-r1 and trail-r2 and activetes them |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | down-regulates quantity by repression
transcriptional regulation
|
TNFSF10 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253895 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22128144 |
We observe that the CD8(+) T-cell autocrine growth factor IL-2 coordinately increases Nab2 expression and decreases TRAIL expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
TNFSF10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253893 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22128144 |
In the present study, we investigated the molecular basis for the differential regulation of TRAIL in helped versus helpless CD8(+) T cells by comparing their transcriptional profiles, and have identified a transcriptional corepressor, NGFI-A binding protein 2 (Nab2), that is selectively induced in helped CD8(+) T cells. Enforced expression of Nab2 prevents TRAIL induction after restimulation of primary helpless CD8(+) T cells, and expression of a dominant-negative form of Nab2 in helped CD8(+) T cells impairs their secondary proliferative response that is reversible by TRAIL blockade. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFSF10 | up-regulates quantity by expression
post transcriptional regulation
|
NFKB1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277936 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 23647548 |
Treatment with TRAIL increased the NF-κB transcriptional activity by approximately twofold in MDA-MB-231 cells compared to the control. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF10D | down-regulates
binding
|
TNFSF10 |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9382840 |
One function of trail-r4 may be inhibition of trail cytotoxicy. Dcr2 functions as an inhibitory apo2l receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TNFSF10
- 
- 