Summary

Name SH2B2
Full Name SH2B adapter protein 2
Synonyms Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS | APS
Primary ID O14492
Links - -
Type protein
Relations 8
Function Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SH2B2 0.01
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation SH2B2 0.01
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SH2B2
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation SH2B2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding CBL 0.40
Publications: 2 Organism: Cricetulus Griseus, Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png binding INSR 0.15
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation SH2B2 0.09
Publications: 1 Organism: Homo Sapiens