3.0
Summary
| Name |  SH2B2View Modifications |
| Full Name | SH2B adapter protein 2 |
| Synonyms | Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS | APS |
| Primary ID | O14492 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates activity 
phosphorylation
|
SH2B2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | AKT1 |
phosphorylation
|
SH2B2 | 0.409 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | AKT1 | up-regulates activity
phosphorylation
|
SH2B2 | 0.409 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | AKT |
phosphorylation
|
SH2B2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NTRK1 | up-regulates
phosphorylation
|
SH2B2 | 0.531 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SH2B2 | up-regulates
binding
|
CBL | 0.631 |
| Publications: | 2 | Organism: | Homo Sapiens, Cricetulus Griseus | |
| Tissue: | Ovary | |||
| + | SH2B2 | down-regulates 
binding
|
INSR | 0.604 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||
| + | PTEN | up-regulates quantity by expression 
transcriptional regulation
|
SH2B2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |