| + |
BHLHE41 | down-regulates quantity by repression 
transcriptional regulation
|
BHLHE40 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253714 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14672706 |
We show here an autofeedback loop of Dec1 encoding a basic helix–loop–helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and DEC1 and DEC2 as well as PERs and CRYs suppressed the induced expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NR1H3 | up-regulates quantity by expression 
transcriptional regulation
|
BHLHE40 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253691 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19032342 |
LXRα and LXRβ are potent positive regulators for hepatic Dec1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CLOCK/BMAL1 | up-regulates quantity by expression
transcriptional regulation
|
BHLHE40 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253707 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19032342 |
DEC1 (BHLHB2/Stra13/Sharp2)-a basic helix-loop-helix transcription factor-is known to be involved in various biological phenomena including clock systems and metabolism. In the clock systems, Dec1 expression is dominantly up-regulated by CLOCK : BMAL1 heterodimer, and it exhibits circadian rhythm in the suprachiasmatic nucleus (SCN)-the central circadian pacemaker-and other peripheral tissues. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BHLHE40 | down-regulates quantity by repression
transcriptional regulation
|
BHLHE41 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253716 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 14672706 |
Forced expression of Clock/Bmal increased endogenous Dec1 mRNA level, and overexpression of Dec1 resulted in suppression of Dec2, Per2, and Dbp expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BHLHE40 | down-regulates quantity by repression
transcriptional regulation
|
BHLHE40 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253715 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 14672706 |
We show here an autofeedback loop of Dec1 encoding a basic helix–loop–helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and DEC1 and DEC2 as well as PERs and CRYs suppressed the induced expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NR1H2 | up-regulates quantity by expression
transcriptional regulation
|
BHLHE40 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253690 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19032342 |
LXRα and LXRβ are potent positive regulators for hepatic Dec1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BHLHE40 | down-regulates quantity by repression
transcriptional regulation
|
PER2 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253717 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 14672706 |
Forced expression of Clock/Bmal increased endogenous Dec1 mRNA level, and overexpression of Dec1 resulted in suppression of Dec2, Per2, and Dbp expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
UBE2I | down-regulates quantity by destabilization 
polyubiquitination
|
BHLHE40 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272579 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11278694 |
Co-expression of STRA13 and UBC9 led to an increase of the pSTRA13 ubiquitination and subsequent degradation. These data established that UBC9/STRA13 association in cells is of physiological importance, presenting direct proof of UBC9 involvement in the ubiquitin-dependent degradation of pSTRA13. We also checked whether UBC9 is directly involved in pSTRA13 ubiquitination. Taken together, these results strongly suggest that pSTRA13 is targeted for proteolysis by the ubiquitin-dependent proteasome pathway through association with UBC9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BHLHE40
- 
- 