Summary

Name BHLHE41
Full Name Class E basic helix-loop-helix protein 41
Synonyms bHLHe41, Class B basic helix-loop-helix protein 3, bHLHb3, Differentially expressed in chondrocytes protein 2, hDEC2, Enhancer-of-split and hairy-related protein 1, SHARP-1 | BHLHB3, DEC2, SHARP1
Primary ID Q9C0J9
Links - -
Type protein
Relations 4
Function Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BHLHE41 0.511
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding BHLHE41 0.268
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BHLHE40 0.511
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding BHLHE41 0.2
Publications: 1 Organism: Homo Sapiens