Summary

Name NDC80
Full Name Kinetochore protein NDC80 homolog
Synonyms Highly expressed in cancer protein, Kinetochore protein Hec1, HsHec1, Kinetochore-associated protein 2, Retinoblastoma-associated protein HEC | HEC, HEC1, KNTC2
Primary ID O14777
Links - -
Type protein
Relations 5
Function Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NDC80 0.843
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NDC80 0.616
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Ndc80 complex 0.965
Publications: 1