Summary

Name HTRA2
Full Name Serine protease HTRA2, mitochondrial
Synonyms High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI | OMI, PRSS25
Primary ID O43464
Links - -
Type protein
Relations 11
Pathways Parkinson disease
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HTRA2 0.49
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Parkinson disease
+ down-regulates img/direct_inhibition.png phosphorylation HTRA2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HTRA2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HTRA2 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ up-regulates img/direct-activation.png phosphorylation HTRA2 0.38
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png relocalization HTRA2 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PEA15 0.67
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization HTRA2 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown HTRA2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown HTRA2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding XIAP 0.68
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease