Summary

Name PIAS4
Full Name E3 SUMO-protein ligase PIAS4
Synonyms PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma | PIASG
Primary ID Q8N2W9
Links - -
Type protein
Relations 9
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PIAS4 0.504
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation RPA2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PIAS4 0.414
Publications: 1
+ down-regulates img/direct_inhibition.png binding SMAD4 0.54
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3/SMAD4 0.584
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding STAT1 0.538
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation TP53BP1 0.618
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD3 0.628
Publications: 1 Organism: Homo Sapiens