Summary

Name MUSK
Full Name Muscle, skeletal receptor tyrosine-protein kinase
Synonyms Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor
Primary ID O15146
Links - -
Type protein
Relations 11
Function Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation DOK7 0.752
Publications: 3 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding WNT11 0.475
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MUSK 0.475
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MUSK 0.413
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding MUSK 0.721
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation MUSK 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity img/direct_inhibition.png ubiquitination MUSK 0.565
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding MUSK 0.752
Publications: 1 Organism: Homo Sapiens