| + |
PKA | up-regulates activity 
phosphorylation
|
GSTA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264796 |
Ser189 |
QEYTVKLsNIPTIKR |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646569 |
Mutational analysis show that the putative mitochondrial targeting signal resides within the C-terminal 20 amino acid residues of the protein and that the targeting signal requires activation by phosphorylation at the C-terminal-most protein kinase A (PKA) site at Ser-189 or protein kinase C (PKC) site at Thr-193. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PKC | up-regulates activity
phosphorylation
|
GSTA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264795 |
Thr193 |
VKLSNIPtIKRFLEP |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12646569 |
Mutational analysis show that the putative mitochondrial targeting signal resides within the C-terminal 20 amino acid residues of the protein and that the targeting signal requires activation by phosphorylation at the C-terminal-most protein kinase A (PKA) site at Ser-189 or protein kinase C (PKC) site at Thr-193. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
HSPA1A | up-regulates activity
relocalization
|
GSTA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264799 |
|
|
|
|
| pmid |
sentence |
| 21929724 |
Model showing Ser189/Thr193 protein kinase dependent phosphorylation of GST A4‐4 has increased affinity for chaperone Hsp70 which activates mitochondrial competent import signals for GSTA4‐4. |Protein kinase A mediated phosphorylation of serine residues of CYPs increases the affinity of proteins for binding to cytoplasmic chaperones such as heat shock proteins (Hsp), Hsp70/Hsp90, resulting in increased mitochondrial translocation |
|
| Publications: |
1 |
| + |
ROS | up-regulates 
|
GSTA4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264797 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12646569 |
We have also provided evidence that the mitochondrial GSTA4-4 level markedly increases in COS cells under oxidative stress conditions, suggesting its critical role in maintaining the GSH homeostasis under conditions of chemical and oxidative stress |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
HSPA1B | up-regulates activity
relocalization
|
GSTA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264800 |
|
|
|
|
| pmid |
sentence |
| 21929724 |
Model showing Ser189/Thr193 protein kinase dependent phosphorylation of GST A4‐4 has increased affinity for chaperone Hsp70 which activates mitochondrial competent import signals for GSTA4‐4. |Protein kinase A mediated phosphorylation of serine residues of CYPs increases the affinity of proteins for binding to cytoplasmic chaperones such as heat shock proteins (Hsp), Hsp70/Hsp90, resulting in increased mitochondrial translocation |
|
| Publications: |
1 |
3.0
GSTA4
- 
- 