+ |
USP7 | up-regulates quantity by stabilization
deubiquitination
|
CHFR |
0.445 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271462 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17442268 |
In this study, we identified USP7 (also known as HAUSP), which is a member of a family of proteins that cleave polyubiquitin chains and/or ubiquitin precursors, as an interacting protein with Chfr by immunoaffinity purification and mass spectrometry, and their interaction greatly increases the stability of Chfr. In fact, USP7 can remove ubiquitin moiety from the autoubiquitinated Chfr both in vivo and in vitro, which results in the accumulation of Chfr in the cell. USP7 mediates deubiquitination of Chfr. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP7 | up-regulates
deubiquitination
|
MDM2 |
0.762 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-139450 |
|
|
Homo sapiens |
|
pmid |
sentence |
16082221 |
Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP7 | up-regulates
deubiquitination
|
TP53 |
0.732 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-139456 |
|
|
Homo sapiens |
|
pmid |
sentence |
16082221 |
Hausp counteracts the destabilizing effect of mdm2 by direct deubiquitination of p53. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | EBV infection |
+ |
USP7 | up-regulates
deubiquitination
|
MDM4 |
0.747 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-139453 |
|
|
Homo sapiens |
|
pmid |
sentence |
16082221 |
Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
USP7 | up-regulates quantity
cleavage
|
Ubiquitin |
0.772 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270837 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Ubiquitin activation |
+ |
USP7 | up-regulates quantity
cleavage
|
UBA52 |
0.716 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270823 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Ubiquitin activation |
+ |
USP7 | up-regulates quantity
cleavage
|
RPS27A |
0.632 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270824 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Ubiquitin activation |