| + |
CSNK2A1 | up-regulates quantity by stabilization 
phosphorylation
|
USP7 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276530 |
Ser18 |
KAGEQQLsEPEDMEM |
|
|
| pmid |
sentence |
| 22361354 |
We find that stabilization of Mdm2, and correspondingly p53 downregulation in unstressed cells, is accomplished by a specific isoform of USP7 (USP7S), which is phosphorylated at serine 18 by the protein kinase CK2. Phosphorylation stabilizes USP7S and thus contributes to Mdm2 stabilization and downregulation of p53. |
|
| Publications: |
1 |
| + |
PPM1G | down-regulates quantity by destabilization 
dephosphorylation
|
USP7 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276531 |
Ser18 |
KAGEQQLsEPEDMEM |
|
|
| pmid |
sentence |
| 22361354 |
We find that stabilization of Mdm2, and correspondingly p53 downregulation in unstressed cells, is accomplished by a specific isoform of USP7 (USP7S), which is phosphorylated at serine 18 by the protein kinase CK2. |After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation of p53. |
|
| Publications: |
1 |
| + |
BCR-ABL | up-regulates activity
phosphorylation
|
USP7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276532 |
Tyr243 |
NQLRKAVyMMPTEGD |
|
|
| pmid |
sentence |
| 24317448 |
In this study, we show that BCR-ABL enhances HAUSP-induced de-ubiquitination of PTEN in turn favoring its nuclear exclusion. We further demonstrate that BCR-ABL physically interacts with and phosphorylates HAUSP on tyrosine residues to trigger its activity.|The HAUSP Y243F mutant showed significantly reduced BCR-ABL-induced HAUSP phosphorylation, which in turn was completely abrogated by imatinib treatment |
|
| Publications: |
1 |
| + |
USP7 | up-regulates
deubiquitination
|
MDM4 |
0.747 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16082221 |
Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP7 | up-regulates quantity
cleavage
|
RPS27A |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270824 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
USP7 | up-regulates quantity
cleavage
|
UBA52 |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270823 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
USP7 | up-regulates quantity
cleavage
|
Ubiquitin |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270837 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
USP7 | up-regulates
deubiquitination
|
TP53 |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139456 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16082221 |
Hausp counteracts the destabilizing effect of mdm2 by direct deubiquitination of p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
USP7 | up-regulates quantity by stabilization
deubiquitination
|
CHFR |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271462 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17442268 |
In this study, we identified USP7 (also known as HAUSP), which is a member of a family of proteins that cleave polyubiquitin chains and/or ubiquitin precursors, as an interacting protein with Chfr by immunoaffinity purification and mass spectrometry, and their interaction greatly increases the stability of Chfr. In fact, USP7 can remove ubiquitin moiety from the autoubiquitinated Chfr both in vivo and in vitro, which results in the accumulation of Chfr in the cell. USP7 mediates deubiquitination of Chfr. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP7 | down-regulates activity
deubiquitination
|
PTEN |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276533 |
|
|
|
|
| pmid |
sentence |
| 24317448 |
BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP|hese data indicate that BCR-ABL phosphorylation of HAUSP modulates HAUSP’s deubiquitinase activity toward PTEN. |
|
| Publications: |
1 |
| + |
PPM1G | down-regulates activity
dephosphorylation
|
USP7 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361354 |
Here, we report that in response to DNA damage USP7 is downregulated by the ATM dependent protein phosphatase PPM1G, thus downregulating Mdm2 and activating the p53 response.|We have now shown that when DNA damage is detected, PPM1G is activated and dephosphorylates USP7 isoform protein that leads to its degradation and consequently to Mdm2 degradation and accumulation of p53 ( A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP7 | up-regulates quantity by stabilization
deubiquitination
|
DEPTOR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277588 |
|
|
in vitro |
|
| pmid |
sentence |
| 35216969 |
Screening the DEPTOR interactome identified that the association of USP-7 deubiquitinase with DEPTOR was dependent upon S235 phosphorylation. Inhibition of USP-7 activity resulted in DEPTOR polyubiquitination and degradation. A scansite search suggested that ERK1 may be responsible for S235 phosphorylation, which was confirmed through the use of inhibitors, ERK1 knockdown, and an in vitro kinase assay. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
USP7 | up-regulates
deubiquitination
|
MDM2 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16082221 |
Subsequently, hausp was shown to deubiquitinate mdm2 and mdmx, thereby stabilizing these proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
USP7
- 
- 