3.0
Summary
| Name |  USP7View Modifications |
| Full Name | Ubiquitin carboxyl-terminal hydrolase 7 |
| Synonyms | Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7 | HAUSP |
| Primary ID | Q93009 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Pathways | EBV infection, Ubiquitin activation |
| Function | Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:26678539, PubMed:28655758). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates quantity by stabilization 
phosphorylation
|
USP7 | 0.38 |
| Publications: | 1 | |||
| + | PPM1G | down-regulates quantity by destabilization 
dephosphorylation
|
USP7 | 0.525 |
| Publications: | 1 | |||
| + | BCR-ABL | up-regulates activity
phosphorylation
|
USP7 | 0.2 |
| Publications: | 1 | |||
| + | USP7 | up-regulates quantity by stabilization
deubiquitination
|
CHFR | 0.443 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP7 | down-regulates activity
deubiquitination
|
PTEN | 0.731 |
| Publications: | 1 | |||
| + | USP7 | up-regulates quantity
cleavage
|
RPS27A | 0.638 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||
| + | PPM1G | down-regulates activity
dephosphorylation
|
USP7 | 0.525 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP7 | up-regulates
deubiquitination
|
MDM2 | 0.762 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP7 | up-regulates quantity by stabilization
deubiquitination
|
DEPTOR | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | USP7 | up-regulates quantity
cleavage
|
UBA52 | 0.722 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||
| + | USP7 | up-regulates
deubiquitination
|
TP53 | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | EBV infection | |||
| + | USP7 | up-regulates
deubiquitination
|
MDM4 | 0.748 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP7 | up-regulates quantity
cleavage
|
Ubiquitin | 0.777 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Ubiquitin activation | |||