Summary

Name OGG1
Full Name N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase
Synonyms OGG1_HUMAN | MMH, MUTM, OGH1
Primary ID O15527
Links - -
Type protein
Relations 5
Function DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

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Relations

Regulator Mechanism target score ℹ
+ NFYAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation OGG1 0.268
Publications: 1 Organism: Homo Sapiens
+ OGG1up-regulates img/indirect-activation.png DNA_repair 0.7
Publications: 1 Organism: Mus Musculus
+ TP53up-regulates quantity by expression img/direct-activation.png transcriptional regulation OGG1 0.441
Publications: 1 Organism: Homo Sapiens
+ CUX2up-regulates activity img/direct-activation.png binding OGG1 0.2
Publications: 1 Organism: Mus Musculus
+ OGG1up-regulates img/indirect-activation.png Base-excision_repair 0.7
Publications: 1