Summary

Name SMAD6
Full Name Mothers against decapentaplegic homolog 6
Synonyms MAD homolog 6, Mothers against DPP homolog 6, SMAD family member 6, SMAD 6, Smad6, hSMAD6 | MADH6
Primary ID O43541
Links - -
Type protein
Relations 15
Pathways TGFbeta Signaling
Function Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination SMAD6 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.67
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates activity img/direct_inhibition.png binding SMAD4 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates img/indirect_inhibition.png unknown BMPR1A 0.74
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.69
Publications: 2 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates img/direct_inhibition.png binding TAB1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MAP3K7
Publications: 1 Organism: Rattus Norvegicus
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png binding HOXC8 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PELI1 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD1 0.95
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR2C2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD6
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates activity img/direct_inhibition.png relocalization SMAD6 0.89
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD1/4
Publications: 1 Organism: Homo Sapiens