| + |
SMURF | down-regulates activity 
ubiquitination
|
SMAD7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12519765 |
Smad ubiquitin regulatory factor 1 (Smurf1), a HECT type E3 ubiquitin ligase, interacts with inhibitory Smad7 and induces translocation of Smad7 to the cytoplasm |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates activity
ubiquitination
|
SMAD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253259 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 15817471 |
Smurfs, which otherwise cannot directly bind to smad4, mediated poly-ubiquitination of smad4 in the presence of smad6 or smad7. Smad signaling is negatively regulated by inhibitory (i) smads and ubiquitin-mediated processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates
ubiquitination
|
BMPR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates
ubiquitination
|
SMAD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates activity
ubiquitination
|
SKIL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11389444 |
Tgf-beta also induces the association of smurf2 with the transcriptional co-repressor snon and we show that smad2 can function to mediate this interaction. This allows smurf2 hect domain to target snon for ubiquitin-mediated degradation by the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293T Cell, Mv1Lu Cell |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates
ubiquitination
|
BMPR1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates
ubiquitination
|
SMAD9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270211 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates activity
ubiquitination
|
TGFBR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17317136 |
Recruitment of ww and hect domain e3-ubiquitin ligases smurf1 and 2 to induce type i receptor ubiquitination and subsequent receptor degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates
ubiquitination
|
SMAD5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270213 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD7 | up-regulates activity 
relocalization
|
SMURF |
0.895 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253258 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19352540 |
Smad7 also recruits the HECT type of E3 ubiquitin ligases, Smurf1 and Smurf2. It binds to Smurfs in the nucleus and translocates into the cytoplasm in response to TGF-_ and recruits the ubiquitin ligases to the activated type I receptor ALK5/T_RI, leading to the degradation of the receptor through the proteasomal pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates activity
ubiquitination
|
TGFBR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253265 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates activity
ubiquitination
|
SMAD2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253263 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11016919 |
The ability of smurf2 to promote smad2 destruction required the hect catalytic activity of smurf2 and depended on the proteasome-dependent pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293 Cell |
| Pathways: | TGF-beta Signaling |
| + |
SMURF | down-regulates activity
relocalization
|
SMAD6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1, with its WW domain, specifically binds to the PY motif of Smad6 and transports Smad6 into the cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
3.0
SMURF