3.0
Summary
| Name |  BUB3View Modifications |
| Full Name | Mitotic checkpoint protein BUB3 |
| Synonyms | BUB3_HUMAN | |
| Primary ID | O43684 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
BUB3 | 0.319 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BUB1 | up-regulates activity
relocalization
|
BUB3 | 0.942 |
| Publications: | 1 | |||
| + | BUB3 | form complex 
binding
|
MCC | 0.965 |
| Publications: | 1 | Organism: | Homo Sapiens | |