4.0
Summary
| Name |  NPHS1View Modifications |
| Full Name | Nephrin |
| Synonyms | Renal glomerulus-specific cell adhesion receptor | NPHN |
| Primary ID | O60500 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | Focal segmental glomerulosclerosis |
| Function | Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates activity 
phosphorylation
|
NPHS1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | AGTR1 | down-regulates activity 
|
NPHS1 | 0.364 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| Pathways: | Focal segmental glomerulosclerosis | |||
| + | SRC | up-regulates activity
phosphorylation
|
NPHS1 | 0.48 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FYN | up-regulates activity
phosphorylation
|
NPHS1 | 0.74 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WT1 | up-regulates quantity by expression
transcriptional regulation
|
NPHS1 | 0.489 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Focal segmental glomerulosclerosis | |||