Summary

Name MYCBP2
Full Name E3 ubiquitin-protein ligase MYCBP2
Synonyms Myc-binding protein 2, Pam/highwire/rpm-1 protein, Protein associated with Myc, RING-type E3 ubiquitin transferase MYCBP2 | KIAA0916, PAM
Primary ID O75592
Links - -
Type protein
Relations 9
Function Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYCBP2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination MYCBP2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MYC 0.426
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png relocalization MYCBP2 0.322
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYCBP2 0.426
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAN 0.303
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding Skp1-Pam E3 0.427
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TSC 0.316
Publications: 1 Organism: Rattus Norvegicus