Summary

Name TSC2
Full Name Tuberin
Synonyms Tuberous sclerosis 2 protein | TSC4
Primary ID P49815
Links - -
Type protein
Relations 38
Function In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation TSC2 0.484
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TSC2 0.418
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TSC2 0.643
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TSC2 0.513
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TSC2 0.558
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.76
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.681
Publications: 3 Organism: Mus Musculus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.667
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.667
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.718
Publications: 6 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.2
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.812
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation TSC2 0.373
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TSC2 0.615
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png RPS6KB2 0.547
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MTOR 0.844
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHEB 0.92
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding TSC1 0.933
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ up-regulates activity img/direct-activation.png phosphorylation TSC2 0.72
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.302
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding TSC 0.933
Publications: 1 Organism: Homo Sapiens