Name	MYCBP2
Full Name	E3 ubiquitin-protein ligase MYCBP2
Synonyms	Myc-binding protein 2, Pam/highwire/rpm-1 protein, Protein associated with Myc, RING-type E3 ubiquitin transferase MYCBP2 \| KIAA0916, PAM
Primary ID	O75592
Links	- -
Type	protein
Relations	9
Function	Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching