| + |
SIRT2 | up-regulates quantity by stabilization 
deacetylation
|
PCK1 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267602 |
Lys594 |
KEVEDIEkYLEDQVN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Conversely, SIRT2 deacetylates and stabilizes PEPCK1.|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267599 |
Lys70 |
EGILRRLkKYDNCWL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Conversely, SIRT2 deacetylates and stabilizes PEPCK1.|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267601 |
Lys71 |
GILRRLKkYDNCWLA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Conversely, SIRT2 deacetylates and stabilizes PEPCK1.|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
EP300 | down-regulates quantity by destabilization 
acetylation
|
PCK1 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267604 |
Lys594 |
KEVEDIEkYLEDQVN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase|P300 Acetylates and Destabilizes PEPCK1|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267597 |
Lys70 |
EGILRRLkKYDNCWL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase|P300 Acetylates and Destabilizes PEPCK1|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267603 |
Lys71 |
GILRRLKkYDNCWLA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase|P300 Acetylates and Destabilizes PEPCK1|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ZNF692 | down-regulates quantity by repression 
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150556 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17097062 |
In this study, we demonstrate that a newly identified transcription factor, arebp, is a novel target of ampk. Arebps function is to repress transcription of the pepck gene upon phosphorylation by ampk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCK1 | down-regulates quantity
chemical modification
|
oxaloacetate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30193097 |
 PCK1 regulates an essential rate-limiting step by catalyzing the reversible conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
UBR5 | down-regulates quantity by destabilization
ubiquitination
|
PCK1 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267600 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase |UBR5 ubiquitinates the acetylated PEPCK1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BAG6 | down-regulates quantity by destabilization
acetylation
|
PCK1 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267598 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
These results indicate that BAT3 and P300 can both exist in the PEPCK1 protein complex, suggesting the possibility that BAT3 could be an enhancer of PEPCK1 acetylation. | indicating a synergistic effect of BAT3 and P300 to promote PEPCK1 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
metformin | down-regulates quantity
|
PCK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBTB46 | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277987 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 30962287 |
We identified LIF/ZBTB46 signalling as a key promoter of metabolic reprogramming and NE differentiation of PCa cells through interactions with PCK1. We showed that ZBTB46 directly upregulates the expression of PCK1 and NE marker gene through activation of LIF signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity 
transcriptional regulation
|
PCK1 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253056 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11069927 |
In the liver, glucocorticoids induce a 10-15-fold increase in the rate of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene, which encodes a key gluconeogenic enzyme |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256107 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
These results reveal that CRTC2 plays an essential role in the regulation of hepatic gluconeogenesis through coordinated regulation of the glucocorticoid/GR- and glucagon/CREB-signaling pathways on the key genes G6P and PEPCK. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
PCK1 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
These results reveal that CRTC2 plays an essential role in the regulation of hepatic gluconeogenesis through coordinated regulation of the glucocorticoid/GR- and glucagon/CREB-signaling pathways on the key genes G6P and PEPCK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Pgc1alfa is thought to mediate transcription downstream of the nuclear receptor hepatocyte nuclear factor 4alfa (hnf4alfa) and the transcription factor foxo1 in the promoters of key gluconeogenic enzymes, including glucose-6-phosphatase (g6pase) and phosphoenolpyruvate carboxylase (pepck) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Pgc1alfa is thought to mediate transcription downstream of the nuclear receptor hepatocyte nuclear factor 4alfa (hnf4alfa) and the transcription factor foxo1 in the promoters of key gluconeogenic enzymes, including glucose-6-phosphatase (g6pase) and phosphoenolpyruvate carboxylase (pepck) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PCK1 | up-regulates quantity
chemical modification
|
phosphonatoenolpyruvate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30193097 |
 PCK1 regulates an essential rate-limiting step by catalyzing the reversible conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
3.0
PCK1
- 
- 