| + |
SIRT2 | up-regulates quantity by stabilization 
deacetylation
|
PCK1 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267602 |
Lys594 |
KEVEDIEkYLEDQVN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Conversely, SIRT2 deacetylates and stabilizes PEPCK1.|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267599 |
Lys70 |
EGILRRLkKYDNCWL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Conversely, SIRT2 deacetylates and stabilizes PEPCK1.|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267601 |
Lys71 |
GILRRLKkYDNCWLA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Conversely, SIRT2 deacetylates and stabilizes PEPCK1.|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
EP300 | down-regulates quantity by destabilization 
acetylation
|
PCK1 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267604 |
Lys594 |
KEVEDIEkYLEDQVN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase|P300 Acetylates and Destabilizes PEPCK1|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267597 |
Lys70 |
EGILRRLkKYDNCWL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase|P300 Acetylates and Destabilizes PEPCK1|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267603 |
Lys71 |
GILRRLKkYDNCWLA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase|P300 Acetylates and Destabilizes PEPCK1|Furthermore, coexpression of P300 increased acetylation levels of wild-type PEPCK1, but not PEPCK13K/R, indicating that P300 acts on these lysine residues of PEPCK1 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression 
transcriptional regulation
|
PCK1 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Pgc1alfa is thought to mediate transcription downstream of the nuclear receptor hepatocyte nuclear factor 4alfa (hnf4alfa) and the transcription factor foxo1 in the promoters of key gluconeogenic enzymes, including glucose-6-phosphatase (g6pase) and phosphoenolpyruvate carboxylase (pepck) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Pgc1alfa is thought to mediate transcription downstream of the nuclear receptor hepatocyte nuclear factor 4alfa (hnf4alfa) and the transcription factor foxo1 in the promoters of key gluconeogenic enzymes, including glucose-6-phosphatase (g6pase) and phosphoenolpyruvate carboxylase (pepck) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
UBR5 | down-regulates quantity by destabilization
ubiquitination
|
PCK1 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267600 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase |UBR5 ubiquitinates the acetylated PEPCK1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCK1 | down-regulates quantity
chemical modification
|
oxaloacetate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30193097 |
 PCK1 regulates an essential rate-limiting step by catalyzing the reversible conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity
transcriptional regulation
|
PCK1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256107 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
These results reveal that CRTC2 plays an essential role in the regulation of hepatic gluconeogenesis through coordinated regulation of the glucocorticoid/GR- and glucagon/CREB-signaling pathways on the key genes G6P and PEPCK. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253056 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11069927 |
In the liver, glucocorticoids induce a 10-15-fold increase in the rate of transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene, which encodes a key gluconeogenic enzyme |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| + |
ZNF692 | down-regulates quantity by repression 
transcriptional regulation
|
PCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150556 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17097062 |
In this study, we demonstrate that a newly identified transcription factor, arebp, is a novel target of ampk. Arebps function is to repress transcription of the pepck gene upon phosphorylation by ampk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
metformin | down-regulates quantity
|
PCK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
PCK1 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
These results reveal that CRTC2 plays an essential role in the regulation of hepatic gluconeogenesis through coordinated regulation of the glucocorticoid/GR- and glucagon/CREB-signaling pathways on the key genes G6P and PEPCK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PCK1 | up-regulates quantity
chemical modification
|
phosphonatoenolpyruvate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30193097 |
 PCK1 regulates an essential rate-limiting step by catalyzing the reversible conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
BAG6 | down-regulates quantity by destabilization
acetylation
|
PCK1 |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267598 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21726808 |
These results indicate that BAT3 and P300 can both exist in the PEPCK1 protein complex, suggesting the possibility that BAT3 could be an enhancer of PEPCK1 acetylation. | indicating a synergistic effect of BAT3 and P300 to promote PEPCK1 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PCK1
- 
- 