3.0
Summary
| Name |  CACNA1HView Modifications |
| Full Name | Voltage-dependent T-type calcium channel subunit alpha-1H |
| Synonyms | Low-voltage-activated calcium channel alpha1 3.2 subunit, Voltage-gated calcium channel subunit alpha Cav3.2 | |
| Primary ID | O95180 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | down-regulates activity 
phosphorylation
|
CACNA1H | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SCNN1A | up-regulates activity 
binding
|
CACNA1H | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | CACNA1H | up-regulates quantity
relocalization
|
calcium(2+) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | SCNN1G | up-regulates activity
binding
|
CACNA1H | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | SCNN1B | up-regulates activity
binding
|
CACNA1H | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||