3.0
Summary
| Name |  SCNN1GView Modifications |
| Full Name | Amiloride-sensitive sodium channel subunit gamma |
| Synonyms | Epithelial Na(+) channel subunit gamma, ENaCG, Gamma-ENaC, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG |
| Primary ID | P51170 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK1 | down-regulates quantity by destabilization 
phosphorylation
|
SCNN1G | 0.367 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
SCNN1G | 0.284 |
| Publications: | 1 | Organism: | In Vitro | |
| + | Gbeta | down-regulates quantity by destabilization
phosphorylation
|
SCNN1G | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SCNN1G | up-regulates quantity 
relocalization
|
sodium(1+) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SCNN1G | up-regulates activity
binding
|
CACNA1H | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | ERK1/2 | down-regulates quantity by destabilization
phosphorylation
|
SCNN1G | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |