Summary

Name LETM1
Full Name Mitochondrial proton/calcium exchanger protein
Synonyms Leucine zipper-EF-hand-containing transmembrane protein 1 |
Primary ID O95202
Links - -
Type protein
Relations 8
Function Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation LETM1 0.371
Publications: 1 Organism: In Vitro
+ up-regulates img/indirect-activation.png Mitochondrial respiratory chain complex I 0.258
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization potassium(1+) 0.8
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Mitochondrial respiratory chain complex IV 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Mitochondrial respiratory chain complex III 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LETM1 0.48
Publications: 1 Organism: Homo Sapiens