Relation Results

Summary

Name Mitochondrial_biogenesis
Primary ID SIGNOR-PH32
Type phenotype
Description A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts of a mitochondrion
Relations 5
Pathways MTOR Signaling

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Type: Score: Layout: SPV 
0.70.70.70.70.7LETM1Mitochondrial_biogenesisDNAJC11Inner_mitochondrial_membranePPARGC1ABCS1L

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Relations
Regulator
Mechanism
target
score ℹ
+ LETM1up-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-262545 Homo sapiens HeLa Cell
pmid sentence
We hypothesize a working model of the function of BCS1L and LETM1 in mitochondrial biogenesis (Fig. 8E). Because BCS1L is an AAA-ATPase, the following three functions are downstream targets: (1) respiratory chain assembly, (2) mitochondrial morphology maintenance and, (3) LETM1 complex formation. BCS1L functions directly in the formation of mitochondrial tubular networks, in addition to the assembly of the supercomplexes. LETM1 has a distinct role in maintenance of mitochondrial volume and shapes, which helps – in concert with BCS1L – to achieve the efficient assembly of the respiratory chains.
Publications: 1 Organism: Homo Sapiens
+ DNAJC11up-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261147 Mus musculus Motoneuron
pmid sentence
Homozygous mutant mice developed locomotion defects, muscle weakness, spasticity, limb tremor, leucopenia, thymic and splenic hypoplasia, general wasting and early lethality. Neuropathological analysis showed severe vacuolation of the motor neurons in the spinal cord, originating from dilatations of the endoplasmic reticulum and notably from mitochondria that had lost their proper inner membrane organization. T
Publications: 1 Organism: Mus Musculus
+ Inner_mitochondrial_membraneup-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267005
pmid sentence
Mitochondrial phospholipids are important components of this system. Phospholipids make up the characteristic outer and inner membranes that give mitochondria their shape. 
Publications: 1
+ PPARGC1Aup-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-228618 Homo sapiens
pmid sentence
PGC1a is a positive regulator of mitochondrial biogenesis and respiration, adaptive thermogenesis, gluconeogenesis as well as many other metabolic proc
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ BCS1Lup-regulates img/indirect-activation.png Mitochondrial_biogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-262544 Homo sapiens HeLa Cell
pmid sentence
We hypothesize a working model of the function of BCS1L and LETM1 in mitochondrial biogenesis (Fig. 8E). Because BCS1L is an AAA-ATPase, the following three functions are downstream targets: (1) respiratory chain assembly, (2) mitochondrial morphology maintenance and, (3) LETM1 complex formation. BCS1L functions directly in the formation of mitochondrial tubular networks, in addition to the assembly of the supercomplexes. LETM1 has a distinct role in maintenance of mitochondrial volume and shapes, which helps – in concert with BCS1L – to achieve the efficient assembly of the respiratory chains.
Publications: 1 Organism: Homo Sapiens
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