| + |
BCS1L | up-regulates 
|
Mitochondrial_biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262544 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18628306 |
We hypothesize a working model of the function of BCS1L and LETM1 in mitochondrial biogenesis (Fig. 8E). Because BCS1L is an AAA-ATPase, the following three functions are downstream targets: (1) respiratory chain assembly, (2) mitochondrial morphology maintenance and, (3) LETM1 complex formation. BCS1L functions directly in the formation of mitochondrial tubular networks, in addition to the assembly of the supercomplexes. LETM1 has a distinct role in maintenance of mitochondrial volume and shapes, which helps – in concert with BCS1L – to achieve the efficient assembly of the respiratory chains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LETM1 | up-regulates
|
Mitochondrial_biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262545 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18628306 |
We hypothesize a working model of the function of BCS1L and LETM1 in mitochondrial biogenesis (Fig. 8E). Because BCS1L is an AAA-ATPase, the following three functions are downstream targets: (1) respiratory chain assembly, (2) mitochondrial morphology maintenance and, (3) LETM1 complex formation. BCS1L functions directly in the formation of mitochondrial tubular networks, in addition to the assembly of the supercomplexes. LETM1 has a distinct role in maintenance of mitochondrial volume and shapes, which helps – in concert with BCS1L – to achieve the efficient assembly of the respiratory chains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DNAJC11 | up-regulates
|
Mitochondrial_biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261147 |
|
|
Mus musculus |
Motoneuron |
| pmid |
sentence |
| 25111180 |
Homozygous mutant mice developed locomotion defects, muscle weakness, spasticity, limb tremor, leucopenia, thymic and splenic hypoplasia, general wasting and early lethality. Neuropathological analysis showed severe vacuolation of the motor neurons in the spinal cord, originating from dilatations of the endoplasmic reticulum and notably from mitochondria that had lost their proper inner membrane organization. T |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Inner_mitochondrial_membrane | up-regulates
|
Mitochondrial_biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267005 |
|
|
|
|
| pmid |
sentence |
| 25627476 |
Mitochondrial phospholipids are important components of this system. Phospholipids make up the characteristic outer and inner membranes that give mitochondria their shape. |
|
| Publications: |
1 |
| + |
PPARGC1A | up-regulates
|
Mitochondrial_biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23277535 |
PGC1a is a positive regulator of mitochondrial biogenesis and respiration, adaptive thermogenesis, gluconeogenesis as well as many other metabolic proc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
3.0
Mitochondrial_biogenesis