3.0
Summary
| Name |  LETM1View Modifications |
| Full Name | Mitochondrial proton/calcium exchanger protein |
| Synonyms | Leucine zipper-EF-hand-containing transmembrane protein 1 | |
| Primary ID | O95202 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PINK1 | up-regulates activity 
phosphorylation
|
LETM1 | 0.367 |
| Publications: | 1 | Organism: | In Vitro | |
| + | LETM1 | up-regulates quantity
relocalization
|
potassium(1+) | 0.8 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | LETM1 | up-regulates 
|
Mitochondrial respiratory chain complex III | 0.291 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BCS1L | up-regulates activity
binding
|
LETM1 | 0.477 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LETM1 | up-regulates quantity
relocalization
|
calcium(2+) | 0.8 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | LETM1 | up-regulates
|
Mitochondrial respiratory chain complex IV | 0.294 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LETM1 | up-regulates
|
Mitochondrial_biogenesis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LETM1 | up-regulates
|
Mitochondrial respiratory chain complex I | 0.256 |
| Publications: | 1 | Organism: | Homo Sapiens | |