Summary

Name ZFYVE9
Full Name Zinc finger FYVE domain-containing protein 9
Synonyms Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Novel serine protease, NSP, Receptor activation anchor, hSARA, Smad anchor for receptor activation | MADHIP, SARA, SMADIP
Primary ID O95405
Links - -
Type protein
Relations 7
Pathways myCAF signaling in PDAC, Macrophage: TGF beta, TGF-beta Signaling
Function Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ ZFYVE9up-regulates activity img/direct-activation.png relocalization, binding SMAD3 0.855
Publications: 3 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ TGFBR1up-regulates activity img/direct-activation.png binding ZFYVE9 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ TGFBR2up-regulates activity img/direct-activation.png binding ZFYVE9 0.551
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ ZFYVE9up-regulates activity img/direct-activation.png relocalization SMAD2 0.905
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ PMLup-regulates img/direct-activation.png binding ZFYVE9 0.555
Publications: 1 Organism: Homo Sapiens