| + |
PRKAA1 | down-regulates 
phosphorylation
|
CTBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200250 |
Ser158 |
REGTRVQsVEQIREV |
Homo sapiens |
|
| pmid |
sentence |
| 23291169 |
We found that an activated amp-activated protein kinase (ampk) phosphorylates ctbp1 on ser-158 upon metabolic stresses. Moreover, ampk-mediated phosphorylation of ctbp1 (s158) attenuates the repressive function of ctbp1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates
phosphorylation
|
CTBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216604 |
Ser158 |
REGTRVQsVEQIREV |
Homo sapiens |
|
| pmid |
sentence |
| 23291169 |
We found that an activated amp-activated protein kinase (ampk) phosphorylates ctbp1 on ser-158 upon metabolic stresses. Moreover, ampk-mediated phosphorylation of ctbp1 (s158) attenuates the repressive function of ctbp1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
PAK1 | down-regulates activity
phosphorylation
|
CTBP1 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103943 |
Ser158 |
REGTRVQsVEQIREV |
Homo sapiens |
|
| pmid |
sentence |
| 12872159 |
Pak1 phosphorylates ctbp selectively on ser158 within a putative regulatory loop, triggering ctbp cellular redistribution and blocking ctbp ak1 superphosphorylates ctbp and inhibits ctbp dehydrogenase activitycorepressor functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIPK2 | down-regulates
phosphorylation
|
CTBP1 |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134040 |
Ser422 |
AHPPHAPsPGQTVKP |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 15708980 |
Homeodomain-interacting protein kinase-2 mediates ctbp phosphorylation and degradation in uv-triggered apoptosishipk2 phosphorylates ctbp at ser-422 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | down-regulates
phosphorylation
|
CTBP1 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149721 |
Ser422 |
AHPPHAPsPGQTVKP |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 16984892 |
In this study, we found that c-jun nh2-terminal kinase 1 activation triggered ctbp phosphorylation on ser-422 and subsequent degradation, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
AKT1 | down-regulates quantity
phosphorylation
|
CTBP1 |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278304 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20361981 |
Co-expression of Pc2 and Akt1 results in both phosphorylation and ubiquitylation of CtBP1, thereby targeting CtBP1 for degradation.|CtBP1 phosphorylation by Akt1 appears to both decrease dimerization and induce ubiquitylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCRIP1 | down-regulates activity
binding
|
CTBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264776 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25728771 |
CtBP is recruited to promoter elements of target genes by interacting with the DNA-binding transcriptional repressor ZEB1. We found that MCRIP1 binds to CtBP, thereby competitively inhibiting CtBP-ZEB1 interaction. When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1. In this manner, the CtBP co-repressor complex is recruited to, and silences, the E-cadherin promoter by inducing chromatin modifications. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
BRCA1 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21681822 |
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor with oncogenic potential. We found CtBP1 was recruited to the promoter regions of Brca1 and E-cadherin genes in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZEB2 | up-regulates activity 
binding
|
CTBP1 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268953 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12743039 |
The two members of the ZEB family of zinc finger factors (ZEB-1/deltaEF1 and ZEB-2/SIP1) regulate TGFbeta/BMP signaling in opposite ways: ZEB-1/deltaEF1 synergizes with Smad-mediated transcriptional activation, while ZEB-2/SIP1 represses it. Here we report that these antagonistic effects by the ZEB proteins arise from the differential recruitment of transcriptional coactivators (p300 and P/CAF) and corepressors (CtBP) to the Smads. Thus, while ZEB-1/deltaEF1 binds to p300 and promotes the formation of a p300-Smad transcriptional complex, ZEB-2/SIP1 acts as a repressor by recruiting CtBP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
CDH1 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259197 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21681822 |
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor with oncogenic potential. We found CtBP1 was recruited to the promoter regions of Brca1 and E-cadherin genes in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | down-regulates quantity by repression 
transcriptional regulation
|
BRCA1 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23303449 |
Our findings suggest an important role of CtBP1 in the transcriptional control of p16INK4a and Brca1[.]. Breast Cancer Susceptibility Gene 1(Brca1), a core protein in DNA damage repair, was repressed by CtBP1 in melanoma cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCORL1 | up-regulates activity
binding
|
CTBP1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259193 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 17379597 |
BCoR-L1 also interacts with the CtBP corepressor through a CtBP-interacting motif in its amino terminus. Furthermore, BCoR-L1 is located on the E-cadherin promoter, a known CtBP-regulated promoter, and represses the E-cadherin promoter activity in a reporter assay. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
| + |
CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
VDR |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255178 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 18485278 |
We have shown here that the transcriptional repressor protein SLUG inhibits the expression of VDR in human breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | up-regulates activity
binding
|
ZEB2 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16061479 |
Polycomb protein Pc2 acts as an SUMO E3 ligase for SIP1. SIP1 is an active transcription repressor for many transcription factors and target genes. SIP1 Sumoylation Disrupts the Recruitment of the Corepressor CtBP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBL1Y | down-regulates quantity by destabilization
binding
|
CTBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260902 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18374649 |
TBL1 interacts in vivo with CtBP and promote its proteasomal degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
CDKN2A |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259195 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23303449 |
Our findings suggest an important role of CtBP1 in the transcriptional control of p16INK4a and Brca1[.]. Additionally, the inhibitor of cyclin-dependent protein kinases (CDKs), p16INK4a, whose loss has been related to the pathogenesis of melanoma, was repressed by CtBP1 as well. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
| + |
CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
UBE2D3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255174 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 21044962 |
knockdown of SLUG in SLUG-high breast cancer cells elevated the levels of UbcH5c while decreasing the level of cyclin D1 protein. SLUG is recruited at the E2-box sequence at the UbcH5c gene promoter along with the corepressor CtBP1 and the effector HDAC1 to silence the expression of this gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
CLDN7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254105 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 19277896 |
ChIP assays revealed that SNAI1P is recruited on the CLDN7 gene promoter along with the co-repressor CtBP1 and the effector HDAC1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI1 | up-regulates activity 
|
CTBP1 |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254103 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 19277896 |
We propose that CtBP1 is recruited by SNAI1P at the CLDN7 gene promoter indirectly through another yet to be identified protein. Based on our observations, we propose a model for SNAI1P-mediated down regulation of human CLDN7 gene expression by chromatin remodeling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | up-regulates
binding
|
BHLHE41 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141613 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16287852 |
We identify the ctip and ctbp corepressors as novel components of the human rbp-jkappa/sharp-corepressor complex and show that ctip binds directly to the sharp repression domain. Functionally, ctip and ctbp augment sharp-mediated repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CTBP1
- 
- 