Relation Results

Summary

Name CTBP1
Full Name C-terminal-binding protein 1
Synonyms CtBP1 | CTBP
Primary ID Q13363
Links - -
Type protein
Relations 20
Pathways Acute Myeloid Leukemia, ASXL1 in AML
Function Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium betw ...
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Type: Score: Layout: SPV 
0.410.20.20.3640.4790.20.4770.4910.20.4820.5910.20.2670.5920.4820.20.4440.3560.419PAK1CTBP1PRKAA1AMPKMAPK8HIPK2TBL1YSNAI1AKT1UBE2D3ZEB2CDH1MCRIP1BHLHE41BRCA1CLDN7BCORL1VDRCDKN2A

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PAK1down-regulates activity img/direct_inhibition.png phosphorylation CTBP1 0.41
Identifier Residue Sequence Organism Cell Line
SIGNOR-103943 Ser158 REGTRVQsVEQIREV Homo sapiens
pmid sentence
Pak1 phosphorylates ctbp selectively on ser158 within a putative regulatory loop, triggering ctbp cellular redistribution and blocking ctbp ak1 superphosphorylates ctbp and inhibits ctbp dehydrogenase activitycorepressor functions.
Publications: 1 Organism: Homo Sapiens
+ PRKAA1down-regulates img/direct_inhibition.png phosphorylation CTBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-200250 Ser158 REGTRVQsVEQIREV Homo sapiens
pmid sentence
We found that an activated amp-activated protein kinase (ampk) phosphorylates ctbp1 on ser-158 upon metabolic stresses. Moreover, ampk-mediated phosphorylation of ctbp1 (s158) attenuates the repressive function of ctbp1
Publications: 1 Organism: Homo Sapiens
+ AMPKdown-regulates img/direct_inhibition.png phosphorylation CTBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-216604 Ser158 REGTRVQsVEQIREV Homo sapiens
pmid sentence
We found that an activated amp-activated protein kinase (ampk) phosphorylates ctbp1 on ser-158 upon metabolic stresses. Moreover, ampk-mediated phosphorylation of ctbp1 (s158) attenuates the repressive function of ctbp1
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ MAPK8down-regulates img/direct_inhibition.png phosphorylation CTBP1 0.364
Identifier Residue Sequence Organism Cell Line
SIGNOR-149721 Ser422 AHPPHAPsPGQTVKP Homo sapiens Lung Cancer Cell
pmid sentence
In this study, we found that c-jun nh2-terminal kinase 1 activation triggered ctbp phosphorylation on ser-422 and subsequent degradation,
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ HIPK2down-regulates img/direct_inhibition.png phosphorylation CTBP1 0.479
Identifier Residue Sequence Organism Cell Line
SIGNOR-134040 Ser422 AHPPHAPsPGQTVKP Homo sapiens NCI-H1299 Cell
pmid sentence
Homeodomain-interacting protein kinase-2 mediates ctbp phosphorylation and degradation in uv-triggered apoptosishipk2 phosphorylates ctbp at ser-422
Publications: 1 Organism: Homo Sapiens
+ TBL1Ydown-regulates quantity by destabilization img/direct_inhibition.png binding CTBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260902 Homo sapiens
pmid sentence
TBL1 interacts in vivo with CtBP and promote its proteasomal degradation
Publications: 1 Organism: Homo Sapiens
+ SNAI1up-regulates activity img/indirect-activation.png CTBP1 0.477
Identifier Residue Sequence Organism Cell Line
SIGNOR-254103 Homo sapiens MDA-MB-468 Cell
pmid sentence
We propose that CtBP1 is recruited by SNAI1P at the CLDN7 gene promoter indirectly through another yet to be identified protein. Based on our observations, we propose a model for SNAI1P-mediated down regulation of human CLDN7 gene expression by chromatin remodeling
Publications: 1 Organism: Homo Sapiens
+ AKT1down-regulates quantity img/direct_inhibition.png phosphorylation CTBP1 0.491
Identifier Residue Sequence Organism Cell Line
SIGNOR-278304 Homo sapiens
pmid sentence
Co-expression of Pc2 and Akt1 results in both phosphorylation and ubiquitylation of CtBP1, thereby targeting CtBP1 for degradation.|CtBP1 phosphorylation by Akt1 appears to both decrease dimerization and induce ubiquitylation.
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation UBE2D3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255174 Homo sapiens Breast Cancer Cell Line
pmid sentence
knockdown of SLUG in SLUG-high breast cancer cells elevated the levels of UbcH5c while decreasing the level of cyclin D1 protein. SLUG is recruited at the E2-box sequence at the UbcH5c gene promoter along with the corepressor CtBP1 and the effector HDAC1 to silence the expression of this gene.
Publications: 1 Organism: Homo Sapiens
+ CTBP1up-regulates activity img/direct-activation.png binding ZEB2 0.482
Identifier Residue Sequence Organism Cell Line
SIGNOR-225484 Homo sapiens
pmid sentence
Polycomb protein Pc2 acts as an SUMO E3 ligase for SIP1. SIP1 is an active transcription repressor for many transcription factors and target genes. SIP1 Sumoylation Disrupts the Recruitment of the Corepressor CtBP
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.591
Identifier Residue Sequence Organism Cell Line
SIGNOR-259197 Homo sapiens
pmid sentence
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor with oncogenic potential. We found CtBP1 was recruited to the promoter regions of Brca1 and E-cadherin genes in breast cancer cells.
Publications: 1 Organism: Homo Sapiens
+ MCRIP1down-regulates activity img/direct_inhibition.png binding CTBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264776 Homo sapiens HEK-293 Cell
pmid sentence
CtBP is recruited to promoter elements of target genes by interacting with the DNA-binding transcriptional repressor ZEB1. We found that MCRIP1 binds to CtBP, thereby competitively inhibiting CtBP-ZEB1 interaction. When phosphorylated by ERK, MCRIP1 dissociates from CtBP, allowing CtBP to interact with ZEB1. In this manner, the CtBP co-repressor complex is recruited to, and silences, the E-cadherin promoter by inducing chromatin modifications.
Publications: 1 Organism: Homo Sapiens
+ CTBP1up-regulates img/direct-activation.png binding BHLHE41 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-141613 Homo sapiens
pmid sentence
We identify the ctip and ctbp corepressors as novel components of the human rbp-jkappa/sharp-corepressor complex and show that ctip binds directly to the sharp repression domain. Functionally, ctip and ctbp augment sharp-mediated repression.
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BRCA1 0.592
Identifier Residue Sequence Organism Cell Line
SIGNOR-259196 Homo sapiens
pmid sentence
Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor with oncogenic potential. We found CtBP1 was recruited to the promoter regions of Brca1 and E-cadherin genes in breast cancer cells.
Publications: 1 Organism: Homo Sapiens
+ ZEB2up-regulates activity img/direct-activation.png binding CTBP1 0.482
Identifier Residue Sequence Organism Cell Line
SIGNOR-268953 Homo sapiens HEK-293 Cell
pmid sentence
The two members of the ZEB family of zinc finger factors (ZEB-1/deltaEF1 and ZEB-2/SIP1) regulate TGFbeta/BMP signaling in opposite ways: ZEB-1/deltaEF1 synergizes with Smad-mediated transcriptional activation, while ZEB-2/SIP1 represses it. Here we report that these antagonistic effects by the ZEB proteins arise from the differential recruitment of transcriptional coactivators (p300 and P/CAF) and corepressors (CtBP) to the Smads. Thus, while ZEB-1/deltaEF1 binds to p300 and promotes the formation of a p300-Smad transcriptional complex, ZEB-2/SIP1 acts as a repressor by recruiting CtBP.
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CLDN7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254105 Homo sapiens MDA-MB-468 Cell
pmid sentence
ChIP assays revealed that SNAI1P is recruited on the CLDN7 gene promoter along with the co-repressor CtBP1 and the effector HDAC1.
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BRCA1 0.592
Identifier Residue Sequence Organism Cell Line
SIGNOR-259194 Homo sapiens
pmid sentence
Our findings suggest an important role of CtBP1 in the transcriptional control of p16INK4a and Brca1[.]. Breast Cancer Susceptibility Gene 1(Brca1), a core protein in DNA damage repair, was repressed by CtBP1 in melanoma cells.
Publications: 1 Organism: Homo Sapiens
+ BCORL1up-regulates activity img/direct-activation.png binding CTBP1 0.444
Identifier Residue Sequence Organism Cell Line
SIGNOR-259193 Homo sapiens HEK-293T Cell
pmid sentence
BCoR-L1 also interacts with the CtBP corepressor through a CtBP-interacting motif in its amino terminus. Furthermore, BCoR-L1 is located on the E-cadherin promoter, a known CtBP-regulated promoter, and represses the E-cadherin promoter activity in a reporter assay.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ CTBP1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation VDR 0.356
Identifier Residue Sequence Organism Cell Line
SIGNOR-255178 Homo sapiens Breast Cancer Cell Line
pmid sentence
We have shown here that the transcriptional repressor protein SLUG inhibits the expression of VDR in human breast cancer cells.
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2A 0.419
Identifier Residue Sequence Organism Cell Line
SIGNOR-259195 Homo sapiens
pmid sentence
Our findings suggest an important role of CtBP1 in the transcriptional control of p16INK4a and Brca1[.]. Additionally, the inhibitor of cyclin-dependent protein kinases (CDKs), p16INK4a, whose loss has been related to the pathogenesis of melanoma, was repressed by CtBP1 as well.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
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