Relation Results

Summary

Name EFEMP2
Full Name EGF-containing fibulin-like extracellular matrix protein 2
Synonyms Fibulin-4, FIBL-4, Protein UPH1 | FBLN4
Primary ID O95967
Links - -
Type protein
Relations 3
Function Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth musc ...
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Type: Score: Layout: SPV 
0.5640.5610.394LOXEFEMP2ELNFBN1

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Relations
Regulator
Mechanism
target
score ℹ
+ LOXup-regulates activity img/direct-activation.png binding EFEMP2 0.564
Identifier Residue Sequence Organism Cell Line
SIGNOR-252135 Homo sapiens
pmid sentence
Fibulin-4 directly binds LOX, and this interaction enhances fibulin-4 binding to tropoelastin, thus forming a ternary complex that may be critical for elastin cross-linking.
Publications: 1 Organism: Homo Sapiens
+ EFEMP2up-regulates activity img/direct-activation.png binding ELN 0.561
Identifier Residue Sequence Organism Cell Line
SIGNOR-252136 Homo sapiens
pmid sentence
Fibulin-4 directly binds LOX, and this interaction enhances fibulin-4 binding to tropoelastin, thus forming a ternary complex that may be critical for elastin cross-linking.
Publications: 1 Organism: Homo Sapiens
+ FBN1down-regulates activity img/direct_inhibition.png binding EFEMP2 0.394
Identifier Residue Sequence Organism Cell Line
SIGNOR-251860 Homo sapiens
pmid sentence
Fibulin-4 and -5 are extracellular glycoproteins with essential non-compensatory roles in elastic fiber assembly. Both fibulins differentially bound N-terminal fibrillin-1, which strongly inhibited their binding to lysyl oxidase and tropoelastin.
Publications: 1 Organism: Homo Sapiens
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