| + |
APC2 | up-regulates 
binding
|
AXIN1 |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-57673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9601641 |
Human axin (haxin) binds directly to beta-catenin, gsk3 beta, and apc in vitro, and the endogenous proteins are found in a complex in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC2 | up-regulates
binding
|
GSK3B/Axin/APC |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9601641 |
Human axin (haxin) binds directly to beta-catenin, gsk3 beta, and apc in vitro, and the endogenous proteins are found in a complex in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC2 | down-regulates quantity by destabilization 
relocalization
|
CTNNB1 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81545 |
|
|
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 10980707 |
The tumour-suppressing activity of apc largely involves facilitating the proteasome-mediated degradation of b-cateninit is possible that once exported from the nucleus, apc directs b-catenin along the cytoskeletal network to sites of degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
APC2
- 
- 