3.0
Summary
| Name |  HPView Modifications |
| Full Name | Haptoglobin |
| Synonyms | Zonulin | |
| Primary ID | P00738 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | C1RL | up-regulates activity 
cleavage
|
HP | 0.383 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | HP | down-regulates quantity 
binding
|
HBB | 0.764 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HP | form complex 
binding
|
hb:hp | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HP | up-regulates quantity by stabilization
binding
|
APOA1 | 0.723 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HP | down-regulates quantity
binding
|
HBA1 | 0.734 |
| Publications: | 1 | Organism: | Homo Sapiens | |