Summary

Name HP
Full Name Haptoglobin
Synonyms Zonulin |
Primary ID P00738
Links - -
Type protein
Relations 5
Function As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage HP 0.18
Publications: 1 Organism: Chlorocebus Aethiops
+ form complex img/form-complex.png binding hb:hp
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding APOA1
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding HBA1
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding HBB
Publications: 1 Organism: Homo Sapiens