| + |
CD163 | down-regulates quantity by destabilization 
binding
|
hb:hp |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11854029 |
CD163 was identified as the endocytic receptor binding hemoglobin (Hb) in complex with the plasma protein haptoglobin (Hp). This specific receptor-ligand interaction leading to removal from plasma of the Hp-Hb complex-but not free Hp or Hb-now explains the depletion of circulating Hp in individuals with increased intravascular hemolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hemoglobin | form complex 
binding
|
hb:hp |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255284 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11854029 |
CD163 was identified as the endocytic receptor binding hemoglobin (Hb) in complex with the plasma protein haptoglobin (Hp). This specific receptor-ligand interaction leading to removal from plasma of the Hp-Hb complex-but not free Hp or Hb-now explains the depletion of circulating Hp in individuals with increased intravascular hemolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HP | form complex
binding
|
hb:hp |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255283 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11854029 |
CD163 was identified as the endocytic receptor binding hemoglobin (Hb) in complex with the plasma protein haptoglobin (Hp). This specific receptor-ligand interaction leading to removal from plasma of the Hp-Hb complex-but not free Hp or Hb-now explains the depletion of circulating Hp in individuals with increased intravascular hemolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
hb:hp