Summary

Name HP
Full Name Haptoglobin
Synonyms Zonulin |
Primary ID P00738
Links - -
Type protein
Relations 5
Function As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage HP 0.384
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity img/direct_inhibition.png binding HBA1 0.732
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding HBB 0.76
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding APOA1 0.725
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding hb:hp 0.2
Publications: 1 Organism: Homo Sapiens