Summary

Name F12
Full Name Coagulation factor XII
Synonyms Hageman factor, HAF |
Primary ID P00748
Links - -
Type protein
Relations 14
Function Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage F12 0.603
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ up-regulates activity img/direct-activation.png cleavage KLKB1 0.603
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage F12 0.331
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage F12 0.313
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage F12 0.33
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation F12 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding F12 0.644
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ up-regulates img/indirect-activation.png F12 0.7
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding F12 0.307
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ down-regulates activity img/direct_inhibition.png binding F12 0.332
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ up-regulates activity img/direct-activation.png cleavage F11 0.491
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ down-regulates activity img/direct_inhibition.png cleavage F12 0.599
Publications: 1
+ up-regulates activity img/direct-activation.png binding GPIb-IX-V complex 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation F12 0.2
Publications: 1 Organism: Homo Sapiens