Summary

Name REN
Full Name Renin
Synonyms Angiotensinogenase
Primary ID P00797
Links - -
Type protein
Relations 7
Pathways COVID-19 Causal Network, Fibrosis, Focal segmental glomerulosclerosis, SARS-CoV FIBROSIS
Inhibitors aliskiren; aliskiren fumarate
Function Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png cleavage Angiotensin-1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ up-regulates activity img/direct-activation.png cleavage AGT 0.925
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Focal segmental glomerulosclerosis, SARS-CoV FIBROSIS
+ up-regulates img/direct-activation.png binding ATP6AP2 0.771
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Brain, Kidney, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png chemical inhibition REN 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation REN 0.425
Publications: 1 Organism: Homo Sapiens
Pathways:Focal segmental glomerulosclerosis
+ up-regulates activity img/direct-activation.png binding REN 0.925
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Focal segmental glomerulosclerosis, SARS-CoV FIBROSIS
+ down-regulates img/direct_inhibition.png chemical inhibition REN 0.8
Publications: 1 Organism: Homo Sapiens