Summary

Name IRF2BPL
Full Name Probable E3 ubiquitin-protein ligase IRF2BPL
Synonyms Enhanced at puberty protein 1, Interferon regulatory factor 2-binding protein-like | C14orf4, EAP1, KIAA1865
Primary ID Q9H1B7
Links - -
Type protein
Relations 6
Function Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PENK 0.313
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CTNNB1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IRF2BPL 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GNRH1 0.429
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PDYN 0.266
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination IRF2BPL 0.2
Publications: 1 Organism: Homo Sapiens