| + |
PITX1 | up-regulates quantity by expression 
transcriptional regulation
|
LHB |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254920 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SF1 | up-regulates quantity by expression
transcriptional regulation
|
LHB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254915 |
|
|
Mus musculus |
LbetaT2 Cell |
| pmid |
sentence |
| 19106114 |
The human LHB promoter also contains low and high affinity SF1 binding sites. Mutation of these elements or depletion of endogenous SF1 impaired basal and ligand-induced transcription. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LHB | up-regulates 
binding
|
LHCGR |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10446903 |
Hcg is a heterodimeric glycoprotein hormone, consisting of a common? -subunit and a hormone-specific ?-Subunit (2). It binds to the lh receptor (lhr). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
LHB |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254919 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
EGR1 bound to two binding sites on the LHB promoter and this binding was increased by GNRH1. Mutation of either site or knockdown of endogenous EGR1 decreased basal and/or GNRH1-regulated promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
LHB
- 
- 