| + |
PRKG1 | down-regulates activity 
phosphorylation
|
SF1 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249018 |
Ser20 |
PSKKRKRsRWNQDTM |
Rattus norvegicus |
Neuronal Cell Line |
| pmid |
sentence |
| 10449420 |
PKG phosphorylates SF1 at Ser20, which inhibits the SF1-U2AF65 interaction leading to a block of pre-spliceosome assembly. Mutation of Ser20 to Ala or Thr also inhibits the interaction with U2AF65, indicating that Ser20 is essential for binding. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
UHMK1 | up-regulates 
phosphorylation
|
SF1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143837 |
Ser80 |
PPNPEDRsPSPEPIY |
Homo sapiens |
|
| pmid |
sentence |
| 16420481 |
Sf1 is phosphorylated on serines 80 and 82 in vitro and in vivo. Kis can phosphorylate sf1f on serine 80 and 82 with a high efficiency that particularly relies on the anchoring of its uhm domain to sf1. Serine phosphorylation of a conserved ser80-pro81-ser82-pro83 motif rigidifies a long unstructured linker in the sf1 helix hairpin and slightly enhances rna binding. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199793 |
Ser80 |
PPNPEDRsPSPEPIY |
Homo sapiens |
|
| pmid |
sentence |
| 23175611 |
Sf1 is phosphorylated on serines 80 and 82 in vitro and in vivo. Kis can phosphorylate sf1f on serine 80 and 82 with a high efficiency that particularly relies on the anchoring of its uhm domain to sf1. Serine phosphorylation of a conserved ser80-pro81-ser82-pro83 motif rigidifies a long unstructured linker in the sf1 helix hairpin and slightly enhances rna binding. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143841 |
Ser82 |
NPEDRSPsPEPIYNS |
Homo sapiens |
|
| pmid |
sentence |
| 16420481 |
Sf1 is phosphorylated on serines 80 and 82 in vitro and in vivo. Kis can phosphorylate sf1f on serine 80 and 82 with a high efficiency that particularly relies on the anchoring of its uhm domain to sf1. Serine phosphorylation of a conserved ser80-pro81-ser82-pro83 motif rigidifies a long unstructured linker in the sf1 helix hairpin and slightly enhances rna binding. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199797 |
Ser82 |
NPEDRSPsPEPIYNS |
Homo sapiens |
|
| pmid |
sentence |
| 23175611 |
Sf1 is phosphorylated on serines 80 and 82 in vitro and in vivo. Kis can phosphorylate sf1f on serine 80 and 82 with a high efficiency that particularly relies on the anchoring of its uhm domain to sf1. Serine phosphorylation of a conserved ser80-pro81-ser82-pro83 motif rigidifies a long unstructured linker in the sf1 helix hairpin and slightly enhances rna binding. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
SF1 | down-regulates
binding
|
FUS |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9660765 |
We speculate that zfm1 may inhibit transcription driven by the ntds of tls |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF1 | down-regulates
binding
|
EWSR1 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9660765 |
Here we report that zfm1 also interacts withews / overexpression of zfm1 in hepg2 cells represses the transactivation of reporter gene expression driven by gal4-ews-ntd fusion protein and this repression correlates with zfm1 binding to ews. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF1 | up-regulates quantity by expression 
transcriptional regulation
|
LHB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254915 |
|
|
Mus musculus |
LbetaT2 Cell |
| pmid |
sentence |
| 19106114 |
The human LHB promoter also contains low and high affinity SF1 binding sites. Mutation of these elements or depletion of endogenous SF1 impaired basal and ligand-induced transcription. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates activity
binding
|
SF1 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254914 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
SF1
- 
- 