Summary

Name IGF2
Full Name Insulin-like growth factor II
Synonyms IGF-II, Somatomedin-A, T3M-11-derived growth factor
Primary ID P01344
Links - -
Type protein
Relations 5
Pathways Colorectal Carcinoma, Hepatocellular Tumor, Rhabdomyosarcoma
Function The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGF2 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IGF2R 0.758
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding INSR 0.708
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IGF1R 0.809
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IGF2 0.2
Publications: 1 Organism: Homo Sapiens