Relation Results

Summary

Name LIN28A
Full Name Protein lin-28 homolog A
Synonyms Lin-28A, Zinc finger CCHC domain-containing protein 1 | CSDD1, LIN28, ZCCHC1
Primary ID Q9H9Z2
Links - -
Type protein
Relations 5
Function RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency an ...
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Type: Score: Layout: SPV 
0.280.2650.5270.7030.405MAPK3LIN28AMAPK1SOX17/POU5F1SOX2/POU5F1IGF2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK3down-regulates activity img/direct_inhibition.png phosphorylation LIN28A 0.28
Identifier Residue Sequence Organism Cell Line
SIGNOR-277337 Ser200 EEEEEIHsPTLLPEA Homo sapiens HeLa Cell
pmid sentence
Here we show that Lin28a is directly phosphorylated by ERK1/2 kinases at Ser-200. 
Publications: 1 Organism: Homo Sapiens
+ MAPK1down-regulates activity img/direct_inhibition.png phosphorylation LIN28A 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-277338 Ser200 EEEEEIHsPTLLPEA Homo sapiens HeLa Cell
pmid sentence
Here we show that Lin28a is directly phosphorylated by ERK1/2 kinases at Ser-200. 
Publications: 1 Organism: Homo Sapiens
+ SOX17/POU5F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation LIN28A 0.527
Identifier Residue Sequence Organism Cell Line
SIGNOR-269246
pmid sentence
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6).
Publications: 1
+ SOX2/POU5F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation LIN28A 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-269238
pmid sentence
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6).
Publications: 1
+ LIN28Aup-regulates quantity by expression img/direct-activation.png translation regulation IGF2 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-277339 Homo sapiens
pmid sentence
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency
Publications: 1 Organism: Homo Sapiens
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