Summary

Name MMP1
Full Name Interstitial collagenase
Synonyms Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1 | CLG
Primary ID P03956
Links - -
Type protein
Relations 4
Function Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage COL2A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Angiogenesis 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP1 0.14
Publications: 1 Organism: Homo Sapiens