| + |
MMP1 | down-regulates quantity by destabilization 
cleavage
|
COL2A1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272338 |
Gly774 |
RGDVGEKgPEGAPGK |
in vitro |
|
| pmid |
sentence |
| 17318226 |
In vitro, MMP1 initiates degradation of native fibrillar collagens, crucial components of vertebrate extracellular matrix (ECM), by cleaving the peptide bond between Gly775–Ile776 or Gly775–Lys776 in native type I, II or III collagen molecules3,4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256341 |
Gly906 |
EGPPGPQgLAGQRGI |
Homo sapiens |
|
| pmid |
sentence |
| 8609233 |
MMP-1 cleaves type II collagen at the peptide bond Gly906-Leu907 Proteolysis of triple-helical collagen is an important step in the progression toward irreversible tissue damage in osteoarthritis. Earlier work on the expression of enzymes in cartilage suggested that collagenase-1 (MMP-1) contributes to the process. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
MMP13 | down-regulates quantity by destabilization
cleavage
|
COL2A1 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256340 |
Gly906 |
EGPPGPQgLAGQRGI |
Homo sapiens |
|
| pmid |
sentence |
| 8609233 |
Although it appears that MMP-1 and MMP-13 both cleave type II collagen initially at the same site, MMP-13 affects a secondary cleavage to produce a 1/4-size collagen fragment with an NH2 terminus three amino acids removed from the primary cleavage site.The present work has demonstrated expression of MMP-13 in human osteoarthritic cartilage and shown that MMP-13 has significant type II collagen degrading activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX5 | up-regulates quantity by expression 
transcriptional regulation
|
COL2A1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Two other members of the Sox family, L-Sox5 and Sox6, also bind to the 48-bp Col2a1 enhancer and together with Sox9 activate this enhancer as well as the endogenous Col2a1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
COL2A1 |
0.519 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Sox9 which binds and activates this enhancer element, is required for chondrocyte differentiation and for expression of a series of chondrocyte-specific marker genes including Col2a1, Col9a2, Col11a2 and Aggrecan. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
COL2A1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | up-regulates quantity by expression
transcriptional regulation
|
COL2A1 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Two other members of the Sox family, L-Sox5 and Sox6, also bind to the 48-bp Col2a1 enhancer and together with Sox9 activate this enhancer as well as the endogenous Col2a1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL2A1 | up-regulates 
binding
|
A2/b1 integrin |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31881 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7688313 |
Both a2b1- and a1b1- integrins are implicated in chondrocyte adhesion to native collagene i and ii |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL2A1 | up-regulates activity
binding
|
A10/b1 integrin |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253347 |
|
|
Homo sapiens |
Chondrocyte |
| pmid |
sentence |
| 25169886 |
Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL2A1 | up-regulates
binding
|
A10/b1 integrin |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9685391 |
We have isolated a novel collagen type ii binding integrin, a10b1, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
COL2A1
- 
- 